Review Of Synthetic Cannabinoids

Synthetic cannabinoids are chemical agents that are designed on the basis of natural cannabinoids that are found in the plant of cannabis. Cannabinoids have a wide array of positive effects on the health of the user, however, the problem with natural ones is that, firstly, each plant has to be taken proper care of, the weed requires considerable and accurate processing afterward, the usage is specific (smoking or consuming products with cannabis), and the effect is not that predictable.

The point is, the composition of chemical elements and the balance of active agents can vary depending on the harvest, the conditions in which the plant was growing, and other aspects. As a result, the same strain of cannabis can contain a different proportion of active agents caused by peculiarities of harvest, and it is hard to predict the exact influence of such element on the body.

This is one of the reasons why natural cannabinoids are not listed as official medicinal drugs – since it is impossible to identify the “normal” chemical composition of the drug, it is impossible to register the norms to which such drug has to conform. As a result, the relevant authorities cannot recommend such chemical as official treatment (while currently there are numerous initiatives connected to the legal allowance of cannabis usage). Synthetic cannabinoids, on the other hand, and designed medicinal drugs that can contain the exact amount of active agents and therefore a more predicted effect on the body and mind can be expected.

According to the local laws, many countries have banned a list of certain synthetic cannabinoids. The rest of them, however, are not banned officially. The synthetic chemicals are subdivided into seven major groups, and each group consists of several (or even several dozens) of titles. So, there are plenty of those synthetic cannabinoids available for usage. They differ, mostly, according to the level of their influence on the brain’s receptors. Each group and title have an index, and the lower the index, the more powerful is the connection between the active agent and the receptor.

There are numerous different groups to which various types of cannabinoids belong. Some of them include dozens of substances. They all differ by their chemical characteristics as well as by their effects on the body. These groups are the following ones:

1. Classical cannabinoids (dibenzopyrans);

2. Benzoylindoles;

3. Naphthoylindoles;

4. Naphthoylindazoles;

5. Pyrrolobenzoxazines;

6. Naphthylmethylindoles;

7. Phenylacetylindoles;

8. Indole-3-carboxamides;

9. Indole-3-carboxylates;

10. Tetramethylcyclo- propanoylindoles;

11. Indazole-3- carboxamides;

12. Tetramethylcyclo- propanoylindazoles;

13. Naphthoylpyrroles;

14. Eicosanoids;

15. Pyrazolecarboxamides;

16. Allosteric CBR ligands;

17. Endocannabinoid enhancers (inactivation inhibitors);

18. Anticannabinoids (antagonists/inverse agonists/antibodies);

19. Non-classical cannabinoids;

20. Others.

As it becomes obvious from this list, there are about several hundred of different synthetic agents, and to be able to choose one for research or experiment is not an easy business. To do that, one has to know exactly what symptoms to address, and what agent has the needed effect on the body and mind. What is also important is the power of influence of the agent on the user.

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